Appeal No. 1997-2829
Application No. 08/456,090
A. Angiotensin converting enzyme (ACE) inhibitors are
widely used in treating hypertension, congestive heart
failure, acute myocardial infarction and diabetic nephropathy
(Specification, page 1, lines 2-5).
B. One of the side effects often observed in patients
taking ACE inhibitors is a persistent, dry cough that is
refractory to most commonly prescribed cough suppressants
(Specification, page 1, lines 5-7).
C. As acknowledged by appellant, baclofen is known in
the prior art to have antitussive effects (Specification, page
1, lines 14-20).
II. Representative Claims
Claims 1, 7 and 13 are illustrative of the subject matter
on appeal and read as follows:
1. A method for the suppression of the cough which is
associated with the administration of an ACE inhibitor which
comprises administering an ACE cough suppressing amount of
baclofen for a sufficient period of time to suppress the cough
associated with the administration of the ACE inhibitor.
7. A pharmaceutical composition which comprises an ACE
inhibiting effective amount of an ACE inhibitor and an amount
of baclofen which is sufficient to inhibit the cough which is
associated with the administration of an ACE inhibitor.
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