Appeal No. 1997-3116
Application 08/294,953
The examiner relies on the following references:
Granados 5,298,418 Mar. 29, 1994
Granados 5,300,435 Apr. 05, 1994
Wickham et al. (Wickham), “Screening of Insect Cell Lines for the
Production of Recombinant Proteins and Infectious Virus in the Baculovirus
Expression System,” Biotechnol. Prog., Vol. 8, pp 391-396 (1992)
Stiles et al. (Stiles), “Initiation and Characterization of Five Embryonic Cell
Lines From The Cotton Boll Weevil Anthonomus Grandis In a Commercial
Serum-Free Medium,” In Vitro Cell. Dev. Biol., Vol. 28A, pp 355-363 (1992)
Claims 1-8 stand rejected under 35 U.S.C. § 103 over the combination of
Stiles and Granados (‘435).
Claims 9 and 10 stand rejected under 35 U.S.C. § 103 over the
combination of Granados (‘418) and Wickham.
We reverse the rejection of claims 1-8, affirm the rejection of claims 9 and
10, and enter a new ground of rejection under 37 CFR § 1.196(b).
Background
As disclosed by Appellant’s specification, insect cell lines have been used
to produce many different recombinant products. See pages 1-2. The
specification also discloses that use of serum -free medium is important for large-
scale production using insect cells because it is cheaper and contains fewer
extraneous proteins to get rid of during later purification steps. Page 2. Finally,
the specification discloses that an insect cell line had been established in serum-
free medium but asserts that those skilled in the art believed that other insect cell
lines had to be established in serum -containing medium and later adapted to
2
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