Ex parte GRANADOS - Page 7


                  Appeal No. 1997-3116                                                                                     
                  Application 08/294,953                                                                                   

                  claims 1-8.  The rationale underlying the two rejections differs, however, in a way                      
                  that makes Appellant’s argument unpersuasive here.                                                       
                         The examiner rejected claims 9 and 10 on the basis that the claimed,                              
                  deposited cell lines were the same as or not patentably distinct from cell lines                         
                  disclosed by the prior art.  That is, the examiner considered the similarities                           
                  between the T. ni egg-derived cell lines disclosed by the prior art to be sufficient                     
                  to shift the burden to Appellant to show evidence that the claimed cell lines differ                     
                  from the prior art cell lines.  Appellant has neither argued that the similarities are                   
                  insufficient to justify shifting the burden of proof nor come forward with evidence                      
                  of dissimilarity to show that claims 9 and 10 do not encompass the prior art cell                        
                  lines.                                                                                                   
                         Appellant’s only basis for arguing that the claimed cell lines differ from                        
                  those in the prior art is that the prior art cell lines were established in medium                       
                  containing serum, while the claimed cell lines were established in serum-free                            
                  medium.  This difference, however, is not in the properties of the claimed                               
                  products, but rather in the method by which the product was made.  Claims 9 and                          
                  10 are not drawn to a method of making a cell line by establishing it in serum-free                      
                  medium; the claims are to a product.  “[The] patentability of a claim to a product                       
                  does not rest merely on a difference in the method by which that product is                              
                  made.  Rather, it is the product itself which must be new and unobvious.”  In re                         
                  Pilkington, 411 F.2d 1345, 1348, 162 USPQ 145, 147 (CCPA 1969) (emphasis in                              
                  original).  Appellant is arguing that the product is different because the manner in                     
                  which it is made is different.  The patentability of the product, however, must be                       


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