Ex parte GRANADOS - Page 6


                  Appeal No. 1997-3116                                                                                     
                  Application 08/294,953                                                                                   

                  disclosed by Stiles would be successful if applied to the T. ni  cell lines disclosed                    
                  by Granados (‘435).  The rejection of claims 1-8 under 35 U.S.C. § 103 is                                
                  therefore reversed.                                                                                      
                  2.  The rejection of claims 9 and 10.                                                                    
                         The examiner rejected claims 9 and 10 as obvious over Granados (‘418)                             
                  and Wickham.  According to the examiner, “Granados and Wickham et al                                     
                  disclose an insect cell line derived from the eggs of Trichoplusia ni.  Granados                         
                  also discloses that the cell line is susceptible to various baculoviruses.”  Office                      
                  Action (Paper No. 3), page 8.  The examiner considered these similarities                                
                  sufficient to shift the burden to Appellant to show that the claimed cells differ from                   
                  the prior art cells.                                                                                     
                         Appellant argues that “[t]he references relied upon by the Examiner                               
                  merely teach other T. ni cell lines established in media including serum.  This                          
                  rejection should be reversed for all of the reasons for [sic] stated above for the                       
                  reversal of the rejection of claim 1.”  Appeal Brief, page 7.                                            
                         “[W]hen the PTO shows sound basis for believing that the products of the                          
                  applicant and the prior art are the same, the applicant has the burden of showing                        
                  that they are not.”  In re Spada, 911 F.2d 705, 708, 15 USPQ2d 1655, 1658                                
                  (Fed. Cir. 1990).  See also In re Best, 562 F.2d 1252, 195 USPQ 430 (CCPA                                
                  1977).                                                                                                   
                         In responding to the examiner’s rejection of claims 9 and 10, Appellant                           
                  relies on the same “expectation of success” argument that he makes in regard to                          



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