Ex Parte GOEDE et al - Page 4




          Appeal 1997-3391                                                            
          Application 08/212,578                                                      

          effects, either for prior art flupirtine compounds or                       
          pharmaceutical compositions with the scope of the invention.                
                    13. Thus, on this record all we have is applicants'               
          assertion that side effects are reduced when the compositions of            
          claim 1 are used as an analgesic.                                           

                              The examiner's rejection                                
                    14. A final rejection was withdrawn in the Examiner's             
          Answer, where a new ground of rejection was entered (Examiner's             
          Answer, page 3).                                                            
                    15. The examiner has rejected claims 1-7 as being                 
          unpatentable under 35 U.S.C. § 103 over Lobisch, U.S. Patent                
          5,162,346 (1992), Tamás, U.S. Patent 4,748,023 (1988) and Eichel,           
          U.S. Patent 5,238,686 (1993).                                               
                    16. Applicants timely filed a reply brief responding              
          to the examiner's new ground of rejection.                                  
                    17. There was no further response by the examiner.                

                                       Lobisch                                        
                    18. Lobisch reveals that flupirtine "is an analgesic,             
          i.e., it causes an insensibility to pain without anesthesia or              
          loss of consciousness" (col. 1, lines 11-15).                               
                    19. In fact, flupirtine is said to have "a pronounced             
          analgesic effect" (col. 2, lines 23-24).                                    
                    20. According to Lobisch (col. 2, lines 1-6):                     

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