Appeal 1997-3391
Application 08/212,578
Tamás and Eichel
26. Tamás and Eichel describe the use of
pharmaceuticals in the form of sustained release compositions.
27. The Tamás invention is applicable to any active
ingredient and is said to ensure a high active ingredient content
(col. 2, lines 20-22).
28. Release of an active ingredient can take place
within about 8 hours (col. 2, lines 41-43).
29. Tamás reveals the following about the knowledge
possessed by one skilled in the art (col. 5, lines 24-31):
In the case of certain active ingredients the
parameters which ensure optimal release rate (e.g., starting
particle size of the active ingredient, amount of ethyl
cellulose, character and amount of the disintegrating agent,
etc.) cannot be given in advance but are to be determined by
experiments which belong to the obligatory knowledge of the
skilled art worker and can be easily performed.
30. Eichel emphasizes a sustained-release system for
aspirin (col. 1, lines 15-20).
31. With certain drugs, Eichel tells us that "repeated
dosages must be taken at frequent intervals to obtain long term
pain relief" (col. 1, lines 27-29).
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