Appeal 1997-3391
Application 08/212,578
A muscle-relaxing effect was noted following the
intraperitoneal administration of flupirtine in an
analgesically effective dose range, no central side effects
such as ataxia or reduction in spontaneous motility being
observed in the animals treated with flupirtine in the dose
range investigated.
21. Flupirtine apparently can be administered in a
variety of forms, including "tablets, capsules, pills, coated
tablets, suppositories, ointments, gels, creams, powders, dusting
powders, aerosols or in liquid form" (col. 3, lines 9-12).
22. A preferred form is said to be capsules or tablets
containing between 100 mg and 200 mg by weight of flupirtine
(col. 3, lines 15-18).
23. According to Lobisch (col. 3, lines 28-30):
It is for example possible to recommend 1 to 2 capsules
or tablets containing 50 mg to 200 mg of active substance 3
times daily.
24. However, capsules and tablets may contain dosage
units of 50 mg up to 500 mg of flupirtine (col. 4, lines 20-22).
25. The preparation of Lobisch's pharmaceutical
compositions "is effected in conventional manner, it also being
possible to use conventional and customary pharmaceutical
auxiliary substances and other conventional carriers and
diluents" (col. 5, lines 5-9).
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