Appeal No. 1997-4277
Application No. 08/290,038
The references relied upon by the examiner are:
Namikawa et al. (Namikawa), “Long-term human hematopoiesis in the SCID-hu
mouse,” J. Exp. Med., Vol. 172, pp. 1055-1063 (1990)
McCune et al. (McCune), “The SCID-hu mouse: a small animal model for HIV
infection and pathogenesis,” Annu. Rev. Immunol., Vol. 9, pp. 399-429 (1991)
Kyoizumi et al. (Kyoizumi), “Implantation and maintenance of functional human bone
marrow in SCID-hu mice,” Blood, Vol. 79, No. 7, pp. 1704-1711 (1992)
Mombaerts et al. (Mombaerts), “RAG-1-deficient mice have no mature B and T
lymphocytes,” Cell, Vol. 68, pp. 869-877 (1992)
GROUNDS OF REJECTION
Claims 1, 3, 9 and 11 stand rejected under 35 U.S.C. § 103 as being
unpatentable over Kyoizumi.
Claims 5, 7, 14 and 16 stand rejected under 35 U.S.C. § 103 as being
unpatentable over Kyoizumi in view of McCune and Namikawa.
Claim 13 stands rejected under 35 U.S.C. § 103 as being unpatentable over
Kyoizumi in view of McCune.
Claims 4, 8, 12 and 17 stand rejected under 35 U.S.C. § 103 as being
unpatentable over Kyoizumi in view of McCune and Namikawa in view of
Mombaerts.
Claim 18 stands rejected under 35 U.S.C. § 103 as being unpatentable over
McCune in view of Namikawa.
We reverse.
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