Ex parte CHEN et al. - Page 4



                  Appeal No. 1997-4277                                                                                      
                  Application No. 08/290,038                                                                                

                                                      DISCUSSION                                                            
                         In reaching our decision in this appeal, we have given careful consideration                       
                  to the appellants’ specification and claims, and to the respective positions                              
                  articulated by the appellants and the examiner.  We make reference to the                                 
                  examiner’s Answer2 for the examiner’s reasoning in support of the rejection.  We                          
                  further reference appellants’ Brief3 for the appellants’ arguments in favor of                            

                  patentability.                                                                                            
                  THE REJECTIONS UNDER 35 U.S.C. § 103:                                                                     
                         The initial burden of presenting a prima facie case of obviousness rests on                        
                  the examiner.  In re Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d 1443, 1444 (Fed.                             
                  Cir. 1992).                                                                                               
                  Claims 1, 3, 9 and 11:                                                                                    
                         The examiner argues (Answer, page 2) that “Kyoizumi discloses a scid/scid                          
                  mouse having human fetal bone, human fetal liver and human fetal thymus                                   
                  transplanted and grown in juxtaposition.”  The examiner recognizes (Answer, page                          
                  3) that “Kyoizumi differs from the claims in that the reference fails to disclose the                     
                  transplantation of fetal spleen.”  However, the examiner argues [t]he human                               
                  hematolymphoid organs were known in the art to be spleen, bone, thymus, liver,                            
                  lymphnodes [sic], skin and omentum.”  Therefore, the examiner                                             


                                                                                                                            
                  2 Paper No. 16, mailed June 24, 1997.                                                                     
                  3 Paper No. 15, received March 19, 1997.                                                                  

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