Ex parte MIZOGUCHI et al. - Page 5




          Appeal No. 1998-0878                                                        
          Application No. 08/322,749                                                  


          (1966), and to provide a reason why one having ordinary skill               
          in the pertinent art would have been led to modify the prior                
          art or to combine prior art references to arrive at the                     
          claimed invention.  Such reason must stem from some teaching,               
          suggestion or implication in the prior art as a whole or                    
          knowledge generally available to one having ordinary skill in               
          the art.  Uniroyal, Inc. v. Rudkin-Wiley Corp., 837 F.2d 1044,              
          1051, 5 USPQ2d 1434, 1438 (Fed. Cir.), cert. denied, 488 U.S.               
          825 (1988); Ashland Oil, Inc. v. Delta Resins & Refractories,               
          Inc., 776 F.2d 281, 293,                                                    
          227 USPQ 657, 664 (Fed. Cir. 1985), cert. denied, 475 U.S.                  
          1017 (1986); ACS Hosp. Sys., Inc. v. Montefiore Hosp., 732                  
          F.2d 1572, 1577, 221 USPQ 929, 933 (Fed. Cir. 1984).  These                 
          showings by the examiner are an essential part of complying                 
          with the burden of presenting a prima facie case of                         
          obviousness.  Note In re Oetiker, 977 F.2d 1443, 1445, 24                   
          USPQ2d 1443, 1444 (Fed. Cir. 1992).  If that burden is met,                 
          the burden then shifts to the applicant to overcome the prima               
          facie case with argument and/or evidence.  Obviousness is then              
          determined on the basis of the evidence as a whole and the                  
          relative persuasiveness of the arguments.  See Id.; In re                   
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