Interference 102,413 Page 11
Pitha v. Muller
homogenous composition of product. There is no indication
whether crystals are formed. There is no indication whether
the product contained more than one cyclodextrin derivative.
The solubility of the substance in water at room temperature
is reported to be 3.60g/100ml. Dr. Szente states the
solubility was improperly recorded.20
In Sz-20 (PR 173-174 reproduction of PX-19-30), the
experiment took place no later than July 2, 1981, which is the
date indicated on PX-19-37. The oxymercuration-demercuration
of HPBCD also known as 2,6-di-o-allyl-$-cyclodextrin was
described by the experiment. The substance is described as a21
light yellow, glass powder like substance. There is no
indication whether the product contained more than one
cyclodextrin derivative. Dr. Szente states that his attempts
to crystallize the product failed which is the reason the
phrase “no crystals” is used to describe the product. The 22
solubility of the substance in water at 20 C is reported to be o
15.8g/100ml.
20PR page 182, lines 14-15.
21The notebook refers to the substance 2,6-di-o-allyl-$-
cyclodextrin which is another name for hydroxypropyl-beta-
cyclodextrin (HPBCD).
22PR page 175, paragraph 16.
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