Interference 102,413 Page 12
Pitha v. Muller
In Sz-28 (PR 184, PX-19-39), the experiment appears to
have taken place no later than August 17, 1981, which is the
date that appears on the request for analytical testing (PX-
19-40). The oxymercuration-demercuration of hydroxypropyl-
beta-cyclodextrin with dioxane was described by the
experiment. The substance is described as a very hygroscopic
white powder. There is no indication whether crystals were
formed. There is no indication whether the product contained
more than one cyclodextrin derivative. The solubility of the
substance in water at 20 C is reported to be 16g/100ml.o
In Sz-32 (PX-19-44), the product produced from Sz-20 was
solubilized in water with Vitamin A (retinol) and Vitamin D
3.
The experiment took place no later than July 14, 1981, which
is the date indicated on PX-19-45.
In Sz-34 (PR 185, PX-19-46), the products produced from
Sz-8, Sz-11 and Sz-20 were individually solubilized in water
with beta-ionone. The experiments appear to have taken place
on July 19, 1981, which is the date indicated on PX-19-46.
In Sz-36 (PR 185, PX-19-49), the products produced from
Sz-8, Sz-11 and Sz-28 were individually solubilized in water
with beta-carotene. The experiments appear to have taken
place no later than July 29, 1981, which is the date indicated
on the subsequently occurring page PX-19-54.
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