PITHA V. MULLER et al. - Page 31




          Interference 102,413                                      Page 31           
          Pitha v. Muller                                                             
          experiment.  The substance is described as a very hygroscopic               
          white powder.  There is no indication whether crystals were                 
          formed.  There is no indication whether the product of Sz-28                
          contained more than one cyclodextrin derivative.  The                       
          solubility of the substance in water at 20 C is reported to beo                                 
          16g/100ml.                                                                  
               In Sz-36 (PR 186, PX-19-49), the product produced from                 
          Sz-28 was solubilized in water with beta-carotene.  The                     
          experiment took place no later than July 29, 1981, which is                 
          the date indicated on the subsequently occurring page                       
          PX-19-54.                                                                   
               In Sz-40 (PR 187, PX-19-56), the product produced from                 
          Sz-28 was solubilized in water with beta-carotene.  The                     
          experiment took place no later than September 1, 1981, which                
          is the date indicated on the subsequently occurring page                    
          PX-19-66.                                                                   
               In Sz-41 (PR 187, PX-19-57), the product produced from                 
          Sz-28 was solubilized in water with Vitamin D .  The                        
                                                       3                              
          experiment took place no later than September 1, 1981, which                
          is the date indicated on the subsequently occurring page                    
          PX-19-66.                                                                   
               The product Sz-28 has been described as a white powder                 
          and very hygroscopic.  The solubility of the Sz-28 substance                





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