Interference 102,413 Page 32
Pitha v. Muller
in water at 20 C is reported to be 16g/100ml. There is noo
indication whether the product of Sz-28 contained cyclodextrin
derivatives. Pitha directed us to pages Sz-36, Sz-40 and Sz-
41 which establishes that a portion of the product from Sz-28
was solubilized in water with a drug. Dr. Szente’s
declaration states the product of Sz-28 was amorphous and
solubilized in water with various drugs. We have not been 43
directed to evidence which establishes that the product Sz-28
contained cyclodextrin derivatives as required by the count.
The products Sz-36, Sz-40 and Sz-41, all of which incorporate
Sz-28, do not describe an embodiment which falls within the
scope of the count.
e. The product Sz-42
In Sz-42 (PR 187, PX-19-58), the experiment took place no
later than September 1, 1981, which is the date indicated on
the subsequently occurring page PX-19-66. HPBCD was said to
be formed during the experiment. The substance is described
as white solid substance. There is no indication whether
crystals were formed. The solubility of the substance in
water at 20 C is reported to be 16g/100ml.o
43PR page 184, lines 4-15, page 185 line 19 to page 186
line 10, and page 187, lines 4-15.
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