PITHA V. MULLER et al. - Page 10




                 Interference 102,413                                                                                    Page 10                        
                 Pitha v. Muller                                                                                                                        
                          Exhibit PX-19 is said to be a reproduction of the                                                                             
                 laboratory notebook of Dr. Lajos Szente (Sz).   The exhibit                      19                                                    
                 appears to be a bound book with consecutively numbered pages.                                                                          
                 According to the first page of the notebook (PX-19-001), the                                                                           
                 entries in the notebook occurred between the dates of May 15,                                                                          
                 1981 to December 28, 1981.                                                                                                             
                          In Sz-8 (PR 181, PX-19-16), the experiment took place no                                                                      
                 later than June 2, 1981, which is the date indicated on the                                                                            
                 request for analytical services PX-19-16.  The reaction                                                                                
                 product of BCD and epichlorohydrin was said to be formed                                                                               
                 during the experiment.  There was no description of the                                                                                
                 substance formed.  There is no indication that crystals are                                                                            
                 formed.  There is no indication whether the product contained                                                                          
                 more than one cyclodextrin derivative.  The solubility of the                                                                          
                 substance in water at room temperature is reported to be                                                                               
                 approximately 20mg/ml.                                                                                                                 
                          In Sz-11 (PR 182, PX-19-20), the experiment took place no                                                                     
                 later than July 2, 1981, which is the date indicated on PX-19-                                                                         
                 37.  The reaction product of BCD and 1,4 butanediol diglycidyl                                                                         
                 ether was said to be formed during the experiment.  The                                                                                
                 substance formed was described as white and foam like with no                                                                          


                          19PB page 9, lines 16-19.                                                                                                     





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