Interference 102,413 Page 16
Pitha v. Muller
sent out for testing (PX-26). There is no description of the
appearance of the substance formed. There is no indication
whether crystals were formed. There is no indication whether
the product contained more than one cyclodextrin derivative.
The product W-14 was said to be solubilized in water with
various drugs into aqueous media by Dr. Czajkowska. The 28
following is a list of drugs solubilized in water with W-14
and the respective pages from Dr. Czajkowska’s laboratory
notebook on which they appear:
Testosterone, C-161; Progesterone, C-171; and Estradiol, C-
172.29
In W-17 (PR 299, PX-27-28), HPBCD was said to be formed
by the condensation reaction of beta-cyclodextrin and
propylene oxide in aqueous alkali during the experiment.
There is no description of the appearance of the substance
formed. There is no indication whether crystals were formed.
There is no indication whether the product contained more than
one cyclodextrin derivative. The experiments appearing on
pages W-22, W-38, W-48 and W-55 are said to be reproductions
28PB paragraph bridging pages 18-19.
29PR page 285 and 287.
Page: Previous 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Next
Last modified: November 3, 2007