PITHA V. MULLER et al. - Page 13




                 Interference 102,413                                                                                   Page 13                        
                 Pitha v. Muller                                                                                                                       
                          In Sz-40 (PR 187, PX-19-56), the products produced from                                                                      
                 Sz-11 and Sz-28 were individually solubilized in water with                                                                           
                 beta-carotene.  The experiments appear to have taken place no                                                                         
                 later than September 1, 1981, which is the date indicated on                                                                          
                 the subsequently occurring page PX-19-66.                                                                                             
                          In Sz-41 (PR 187, PX-19-57), the product produced from                                                                       
                 Sz-28 was solubilized in water with Vitamin D .  Dr. Szente                                                                           
                                                                                                 3                                                     
                 states the vitamin D  was not decomposed by the solubilization                                                                        
                                                     3                                                                                                 
                 with Sz-28.   The experiment apparently took place no later23                                                                                                                
                 than September 1, 1981, which is the date indicated on the                                                                            
                 subsequently occurring page PX-19-66.                                                                                                 
                          In Sz-42 (PR 187, PX-19-58), the experiment apparently                                                                       
                 took place no later than September 1, 1981, which is the date                                                                         
                 indicated on the subsequently occurring page PX-19-66.  HPBCD                                                                         
                 was said to be formed during the experiment.  The substance is                                                                        
                 described as a white solid substance.  There is no indication                                                                         
                 whether crystals were formed.  There is no indication whether                                                                         
                 the product contained more than one cyclodextrin derivative.                                                                          
                 The solubility of the substance in water at 20 C is reported                      o                                                   
                 to be 16g/100ml.                                                                                                                      




                          23PR page 187, lines 14-16.                                                                                                  





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