Appeal No. 2000-1906
Application No. 09/063,338
adhesive from the same fraction of a blood sample, a position that is not
supported by the prior art.
With respect to the other methods defined in the claims, the prior art is
even further from supporting a prima facie case of obviousness. Each of claims
17, 29, and 42 require the use of platelet-poor plasma as the source of either the
fibrinogen or the clotting factors in the fibrin glue. The instant specification
teaches that the platelet-poor fraction is produced by centrifuging a blood sample
at low speed, removing the platelet-rich fraction, then re-centrifuging at high
speed to precipitate the red and white blood cells. See pages 9 -10. None of the
references cited by the examiner disclose such a platelet-poor plasma fraction,
nor do they suggest using one to make fibrin glue.
centrifugal force causes red and white cells to lodge irreversibly in a first separator.”); see also
column 12, line 53 to column 13, line 19.
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