Appeal No. 1997-1913
Application 08/238,149
not satisfied by intravenous administration of any arbitrary PC.2 Rather, for any given
subject, claim 23 requires intravenous administration of a PC having an objectively
determined transition temperature (a function of the acyl chain composition). The
specification indicates that one such PC can be egg PC.
Williams teaches that intravenous administration of PC (lecithin) results in
regression of atherosclerosis, and attributes this to the ability of intravenously injected
lecithin to form circulating liposomes which "take up cholesterol from many sources,
including the arterial wall.? Page 417, second paragraph. Intravenous administration of
preformed lecithin liposomes has a similar effect. Page 422. According to Williams,
? lecithin liposomes appear ideally suited as injectable, antiatherogenic lipid particles.?
Page 426. The examiner acknowledges that Williams "may not specify the lecithin or PC
used is pure or purified egg (yolk) lecithin." Examiner's Answer, page 3. Appellants agree
2 Natural PC, or lecithin, "comprises a mixture of the diglycerides of fatty acids (e.g.,
stearic, palmitic, myristal, linoleic, and oleic acids) linked to the choline ester of phosphoric
acid and is found in all living plants and animals." Taylor at page 2.
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