Ex parte THORNE et al. - Page 10




              Appeal No. 1997-2080                                                                                         
              Application No. 08/159,939                                                                                   

              determination of obviousness was based on less than the entire claimed subject matter,                       
              the examiner’s conclusion of obviousness is legally unsound and cannot stand.                                
                     On this record, we reverse the examiner’s rejection of claims 21, 22, 24, 29-32 and                   
              35 under 35 U.S.C. § 103.                                                                                    
              Rejection II                                                                                                 
                     Claims 7, 23, 33, and 34 require adjusting the pH of the fermentation broth to about                  
              7.0 after the pH of the fermentation broth has stabilized, and stand rejected under 35                       
              U.S.C. § 103 as being unpatentable over Shumin Na, Kelly and Kato.  The examiner relies                      
              on Kato to establish that “lowering the initial pH of the culture medium greatly increases the               
              molecular weight of pullulans obtained.”  Examiner’s Answer, pages 3 and 4.  From this,                      
              the examiner concludes that “in order to prepare a pullulan of high molecular weight, a                      
              person having ordinary skill in the art . . . would have been motivated to start fermentation                
              at a lower pH and adjust the pH to neutral after the initial fermentation has taken place.”  Id.,            
              page 4.                                                                                                      
                     We disagree.  We find no suggestion in Kato to adjust the pH to neutral after the                     
              initial fermentation has taken place and the pH has stabilized.  Moreover, Kato does                         
              nothing to overcome the underlying deficiency in the examiner’s proposed combination of                      
              the teachings of Shumin Na and Kelly.                                                                        
                     Accordingly, we reverse the examiner’s rejection of claims 7, 23, 33 and 34 under                     
              35 U.S.C. § 103 as well.                                                                                     

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