Ex parte LAURENCIN et al. - Page 8




              Appeal No. 1997-2634                                                                                       
              Application 08/222,662                                                                                     
              regeneration material, until the bone regeneration material hardens and attaches to the                    
              existing bone.  On the other hand, according to Laurencin, the “specific function” of                      
              hydrolytically unstable polyphosphazenes in bone repair “would be to support osteoblast                    
              growth, forming a bone-polymer matrix” (page 963).  Thus, both Elia and Laurencin                          
              discuss the use of polyphosphazenes in the context of bone repair or replacement, but the                  
              specific function of Elia’s porous containment systems is entirely different from that of                  
              Laurencin’s hydrolytically unstable polyphosphazene growth supports.                                       
                     Neither of the additional references cited by the examiner (Schacht and Lee) does                   
              anything to remedy the underlying deficiency in the examiner’s proposed combination of                     
              Elia and Laurencin.                                                                                        
                     We have no doubt that the prior art could be modified in the manner proposed by                     
              the examiner, but the fact that the prior art could be so modified would not have made the                 
              modification obvious unless the prior art suggested the desirability of the modification.  In              
              re Gordon, 733 F.2d 900, 902, 221 USPQ 1125, 1127 (Fed. Cir. 1984).  Here, we find no                      
              reason stemming from the prior art which would have led a person having ordinary skill in                  
              the art to fabricate a hydrolytically unstable polyphosphazene matrix for repair or                        
              replacement of bone with the specific porosity required by the claims.  In our judgment, the               
              only reason or suggestion to combine the references in the manner proposed by the                          
              examiner comes from appellant’s specification.                                                             




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