Appeal No. 1997-2634
Application 08/222,662
1. A polymeric matrix for repair or replacement of bone formed of a biodegradable,
biocompatible polyphosphazene formed from the repeat unit
R
,
-( -P = N -) -
n
,
R ,
wherein R is a side chain selected from the group consisting of aliphatic, aryl,
aralkyl, alkaryl, carboxylic acid, heteroaromatic, carbohydrates, heteroalkyl, halogen,
(aliphatic)amino, heteroaralkyl, di(aliphatic)amino, arylamino, diarylamino, alkylarylamino,
oxyaryl, oxyaliphatic, oxyalkaryl, oxyaralkyl, thioaryl, thioaliphatic, NHC(O)O-(aryl or
aliphatic), -O-[(CH ) O] -CH ) NH , -O-[(CH ) O] -CH ) NH(CH2) SO H, and -O-[(CH ) O] -2 x y 2 x 2 2 x y 2 x x 3 2 x y
(aryl or aliphatic), wherein x is 1-8 and y is an integer of 1 to 20,
wherein the matrix is a porous structure with pore dimensions of between 100 and
250 microns.
10. A method for repair or replacement of bone comprising implanting at a site in
need of repair or replacement a polymeric matrix formed of a biodegradable,
biocompatible polyphosphazene formed from the repeat unit
R
,
-( -P = N -) -
n
,
R ,
wherein R is a side chain selected from the group consisting of aliphatic, aryl,
aralkyl, alkaryl, carboxylic acid, heteroaromatic, carbohydrates, heteroalkyl, halogen,
(aliphatic)amino, heteroaralkyl, di(aliphatic)amino, arylamino, diarylamino, alkylarylamino,
oxyaryl, oxyaliphatic, oxyalkaryl, oxyaralkyl, thioaryl, thioaliphatic, NHC(O)O-(aryl or
aliphatic), -O-[(CH ) O] -CH ) NH , -O-[(CH ) O] -CH ) NH(CH2) SO H, and -O-[(CH ) O] -2 x y 2 x 2 2 x y 2 x x 3 2 x y
(aryl or aliphatic), wherein x is 1-8 and y is an integer of 1 to 20,
wherein the matrix is a porous structure with pore dimensions of between 100 and
250 microns.
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