Ex parte HATSUYUKI et al. - Page 6




          Appeal No. 1997-3416                                       Page 6           
          Application No. 08/339,340                                                  


          active agent of the type as herein called for.  The examiner                
          must identify a particularized suggestion, reason or                        
          motivation to combine references or make the proposed                       
          modification in a manner so as to arrive at the claimed                     
          invention.                                                                  
               In this regard, "evidence of a suggestion, teaching, or                
          motivation to modify a reference may flow from the prior art                
          references themselves, the knowledge of one of ordinary skill               
          in the art, or, in some cases, from the nature of the problem               
          to be                                                                       


























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