Appeal No. 1997-4380
Application No. 08/147,878
Claims 1 and 34 are illustrative of the subject matter on appeal and are
reproduced below:
1. A method for modulating expression of a gene coding for a vascular cell
adhesion molecule selected from the group consisting of VCAM-1,
ICAM-1 and E-selectin comprising contacting cells with an
oligonucleotide moiety consisting of a nucleotide sequence selected from
the group consisting of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ
ID NO:5, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, and SEQ ID
NO:11.
34. An oligonucleotide moiety consisting of a nucleotide sequence selected
from the group consisting of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4,
SEQ ID NO:5, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, and SEQ ID
NO:11.
The references relied upon by the examiner are:
Bielinska et al. (Bielinska), “Regulation of gene expression with double-stranded
phoshorothioate oligonucleotides,” Science, Vol. 250, pp. 997-1000 (1990)
Baeuerle, “The inducible transcription activator NF-RB: regulation by distinct protein
subunits,” Biochimica et Biophysica Acta, Vol. 1072, pp. 63-80 (1991)
Degitz et al. (Degitz), “Cloning and characterization of the 5’ transcriptional
regulatory region of th ehuman intercellular adhesion molecule 1 gene,” J. Biol.
Chem., Vol. 266, No. 21, pp. 14024-14030 (1991)
Montgomery et al. (Montgomery), “Activation of endothelial-leukocyte adhesion
molecule 1 (ELAM-1) gene transcription,” Proc. Natl. Acad. Sci. U.S.A., Vol. 88, pp.
6523-6527 (1991)
Iademarco et al. (Iademarco), “Characterization of the promoter for vascular cell
adhesion molecule-1 (VCAM-1),” J. Biol. Sci., Vol. 267, No. 23, pp. 16323-16329
(1992)
Miller et al. (Miller), “Gene transfer and antisense nucleic acid techniques,”
Parasitology Today, Vol. 10, No. 3, pp. 92-97 (1994)
Wagner, “Gene inhibition using antisense oligodeoxynucleotides,” Nature, Vol. 372,
pp. 333-335 (1994)
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