Ex parte MEDFORD et al. - Page 9


                 Appeal No.  1997-4380                                                                                    
                 Application No.  08/147,878                                                                              
                 215, 219 (CCPA 1980) (citations omitted), our reviewing court has found an                               
                 exception to this general rule where Athe parameter optimized was not recognized                         

                 to be a result effective variable,@ In re Antonie, 559 F.2d 618, 621, 195 USPQ 6, 8                      

                 (CCPA 1977).  On this record, absent the benefit of appellants’ specification, the                       
                 examiner does not identify, and we do not find, a suggestion in the prior art that the                   
                 length of the nucleotide sequence is a result effective variable.  Furthermore, even if                  
                 there was a suggestion in the art that the length of the nucleotide sequence is a                        
                 result effective variable, we do not find a suggestion in the prior art relied upon that                 
                 suggests that the specific nucleotide sequences claimed by SEQ ID NO.                                    
                         To the extent that the references could be combined as the examiner argues,                      
                 the combination is inconsistent with the proper standard for obviousness.  The mere                      
                 fact that the prior art could be so modified would not have made the modification                        
                 obvious unless the prior art suggested the desirability of the modification.  In re                      
                 Laskowski, 871 F.2d 115, 117, 10 USPQ2d 1397, 1398-99 (Fed. Cir. 1989); In re                            
                 Gordon, 733 F.2d 900, 902, 221 USPQ 1125, 1127 (Fed. Cir. 1984).  Here no                                
                 reference applied by the examiner taken alone or collectively teaches the SEQ ID                         
                 NO limitations of each claim on appeal.  The examiner does not identify, and we do                       
                 not find, a suggestion in the prior art relied upon that would indicate that the prior art               
                 should be modified to have the exact sequences in the claims.                                            









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