Ex parte MEDFORD et al. - Page 3


                 Appeal No.  1997-4380                                                                                    
                 Application No.  08/147,878                                                                              
                 Wu-Pong, “Oligonucleotides: opportunities for drug therapy and research,”                                
                 Pharmaceutical Technology, Vol. 18, pp. 102-114 (1994)                                                   
                 Stull et al. (Stull), “Antigene, ribozyme and aptamer nucleic acid drugs: progress and                   
                 prospects,” Pharmaceutical Research, Vol. 12, No. 4, pp. 465-483 (1995)                                  
                                              GROUNDS OF REJECTION                                                        
                         Claims 1, 2, 5, 8 and 15-17 are rejected under 35 U.S.C. 112, first                              
                 paragraph, as being based on an insufficient disclosure to support or enable the                         
                 scope of the claims.                                                                                     
                         Claims 1, 2, 15-17 and 34 are rejected under 35 U.S.C. § 103 as being                            
                 unpatentable over Bielinska in view of Iademarco.                                                        
                         Claims 1, 5, 15 and 16 are rejected under 35 U.S.C. § 103 as being                               
                 unpatentable over Bielinska in view of Degitz.                                                           
                         Claims 1, 8, 15 and 16 are rejected under 35 U.S.C. § 103 as being                               
                 unpatentable over Bielinska in view of Montgomery.                                                       
                         We reverse the rejections under 35 U.S.C. § 103.  We vacate the rejection                        
                 under 35 U.S.C. § 112, first paragraph and remand this application to the examiner                       
                 to reevaluate his enablement issues under the proper legal standards.                                    
                                                     DISCUSSION                                                           
                         In reaching our decision in this appeal, we have given careful consideration                     
                 to the appellants’ specification and claims, and to the respective positions                             
                 articulated by the appellants and the examiner.  We make reference to the                                
                 examiner’s Answer2 for the examiner’s reasoning in support of the rejection.  We                         


                                                                                                                          
                 2 Paper No. 23, mailed June 27, 1997.                                                                    

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