Ex parte WILLIAMS et al. - Page 8




              Appeal No. 1998-0318                                                                     Page 8                 
              Application No. 08/539,466                                                                                      


                      Hulette provides no description of the sampling tube, but it appears from Figure 2 to                   
              be in the shape of what might be called a conventional tube, that is, a right cylinder having                   
              a rounded bottom.  As such, this would constitute exactly the type of tube over which the                       
              appellants believe their invention to be an improvement with regard to handling micro-                          
              samples.  At the very least, the Hulette tube differs from that recited in claim 23 in that it                  
              does not have an inner portion with a convex curved slope.                Charlton discloses a                  
              tube for use in a centrifuge which has an end portion that is internally inwardly sloped to                     
              define a convex curve, in the manner required by claim 23.  Nevertheless, it is our view that                   
              Hulette and Charlton fail to establish a prima facie case of obviousness with regard to the                     
              subject matter recited in claim 23 for lack of suggestion to combine the references in the                      
              manner proposed by the examiner.  It is axiomatic that the mere fact that the prior art                         

              structure could be modified does not make such a modification obvious unless the prior art                      
              suggests the desirability of doing so.  See  In re Gordon, 733 F.2d 900, 902, 221 USPQ                          
              1125, 1127 (Fed. Cir. 1984).  We fail to perceive any teaching, suggestion or incentive                         
              which would have led one of ordinary skill in the art to replace the sample tube disclosed                      
              by Hulette with that of Charlton.  Hulette is concerned with monitoring changes in the optical                  
              characteristics of a reaction volume in a sample tube (column 1, lines 28-36).  While the                       


                      3(...continued)                                                                                         
              Parmer, it appears to us from the examiner’s explanation of the rejection that the                              
              secondary references are to be considered as alternatives.                                                      







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