Ex parte MURCH et al. - Page 7




                  Appeal No. 1998-0370                                                                                                                    
                  Application No. 08/568,410                                                                                                              
                  also discloses that the detergent compositions contain ingredients that are harmless to the                                             

                  human body.  (Column 1, lines 11-18 and column 2, lines 19-22).                                                                         

                           One of ordinary skill in the art equipped with the knowledge of Kitamura, 21 CFR §                                             

                  173.315 and the descriptions of the prior art would have been motivated to form detergent                                               

                  compositions of Kitamura employing only components which are                                                                            

                  generally regarded as safe because the compositions would be used to clean fruits and                                                   

                  vegetables.   As stated above, the prior art discloses components used to clean fruits and                                              

                  vegetables must not harm humans.  Thus, one of ordinary skill in the art, when forming                                                  

                  Kitamura’s composition for washing fruits and vegetables, would have recognized that the                                                

                  composition should contain ingredients that were not harmful to humans.  Knowledge                                                      

                  generally available to one skilled in the art can provide the motivation to combine the                                                 

                  relevant teachings.  Ashland Oil, Inc. v. Delta Resins & Refractories, Inc., 776 F.2d 281,                                              

                  297 n.24, 227 USPQ 657, 667 n.24 (Fed. Cir. 1985).  The motivation to combine the                                                       

                  relevant teachings of references may come from knowledge of those skilled in the art that                                               

                  certain references, or disclosures in the references, are known to be of special interest or                                            

                  importance in the particular field.  Pro-Mold and Tool Co. v. Great Lakes Plastics Inc.,                                                

                  75 F.3d 1568, 1573, 37 USPQ2d 1626, 1630 (Fed. Cir. 1996).                                                                              

                           Appellants argue that it would not be obvious to eliminate the essential protease                                              

                  inhibitor of Kitamura based upon the Code of Federal Regulations.  (Brief, page 3, third                                                


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