Ex parte ITO et al. - Page 6


                 Appeal No.  1998-1880                                                                                   
                 Application No.  08/423,865                                                                             
                 collecting expired gas.”  Notwithstanding this difference the examiner finds (Answer,                   
                 page 5) that:                                                                                           
                                It would have been obvious to one of ordinary skill in the art at                        
                        the time the invention was made to collect gas in the gastric cavity                             
                        because Hamilton teaches ammonia is produced in the gastric cavity                               
                        after ingestion of urea.  One desiring to detect the presence of H.                              
                        pylori would then be taught the presence of ammonia in the gastric                               
                        cavity is indicative of the presence of H. pylori irrespective of how it is                      
                        collected.                                                                                       
                        The examiner reaffirms this position in his Supplemental Answer (page 2)                         
                 stating that “[i]t is the examiner’s position that collecting the same gas from any site                
                 where that same gas is known to be found is rendered obvious by a known method                          
                 of collecting the same gas from any known site.                                                         
                        In response, appellants’ argue (Reply Brief, bridging paragraph, pages 1-2)                      
                 that the examiner “has not established that it would have been obvious to modify the                    
                 disclosure in Hamilton by collecting gas from the gastric cavity rather than collecting                 
                 expired gas.”  We agree.  While a person of ordinary skill in the art may possess the                   
                 requisite knowledge and ability to modify the protocol taught by Hamilton, the                          
                 modification is not obvious unless the prior art suggested the desirability of the                      
                 modification.  In re Gordon, 733 F.2d 900, 902, 211 USPQ 1125, 1127 (Fed. Cir.                          
                 1984).  Here we see no such reason to modify Hamilton to obtain the claimed                             
                 method which requires obtaining and measuring the amounts of ammonia and                                
                 organic amines in gastric cavity gas that has not traversed the circulatory system to                   
                 be expired in alveolar air.  With regard to the examiner’s unsupported conclusion                       
                 (Supplemental Answer, page 2) that it would be obvious to collect gas from any site                     
                 where it is known to be found, we remind the examiner that, selective hindsight is no                   

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