Appeal No. 1998-1987
Application No. 07/915,783
68. A water-insoluble composition having the characteristic of
inducing in animals immunological reactivity to plasmodial
parasites, said composition comprising recovered parasite
antigenic factor(s) selected from the group consisting of
intact starting plasmodial parasites released from a quantity
of red blood cells, intact red blood cells containing a blood
stage ofsaid starting plasmodial parasite, merozoites which
released themselves from red blood cells, tissues having
blood infected with said starting plasmodial parasite, and
tissues having starting plasmodial parasite infected blood,
said group being treated as follows:
a) forming a suspension in water of said intact starting
plasmodial parasite released from a quantity of red
blood cells, intact red blood cells containing the blood
stage of the starting plasmodial parasite, merozoites
which released themselves from red blood cells,
tissure having blood with said starting plasmodial
parasite, and tissues having starting plasmodial
parasite infected blood, which together contain said
antigenic factor(s), form an aqueous medium;
b) adding a non-ionic detergent to the suspension to
disperse the antigenic factor(s); and
c) separating and recovering the antigenic factor(s) from
the aqueous medium.
18. The composition of Claim 68, wherein the detergent is
selected from the group consisting of MEGA-9, n-heptyl –D-
thioglucoside, Triton X-100 and Nonident P-40.
84. A process for making a composition comprising recovered parasite
antigenic factor(s), said process comprising:
a) forming a suspension in an aqueous medium of at
least one of the following: (i) intact plasmodial
parasite released from a quantity of red blood cells,
(ii) intact red blood cells containing the blood stage of
the plasmodial parasite, (iii) merozoites which
released themselves from red blood cells, (iv) tissues
having blood infected with said plasmodial parasite,
and (v) tissues having plasmodial parasite infected
blood, said suspension having said antigenic factor(s)
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