Ex parte LINDOR - Page 6




              Appeal No. 1998-2267                                                                                       
              Application 08/339,084                                                                                     



              which can be correlated to any human liver disease, much less the treatment of NASH.                       
              Declaration, page 3.  In sum, appellant argues the examiner has failed to show that one of                 
              ordinary skill in the art would consider the conditions of Podda and Shironaga to be                       
              equivalents of NASH.  Brief, pages 11-12.                                                                  
                     In response to appellant’s arguments and evidence, the examiner indicates that the                  
              rejection of the claims “is not based on any asserted <equivalency' between the liver                      
              disorders discussed herein, but instead on certain significant known similarities between                  
              these disorders and NASH which would have provided ample motivation or suggestion to                       
              one of ordinary skill in the art to arrive at the claimed invention.”   Answer, page 10.                   
                     A conclusion of prima facie obviousness, of course, does not end a patentability                    
              determination under 35 U.S.C. § 103.  As stated in In re Hedges, 783 F.2d 1038, 1039,                      
              228 USPQ 685, 686 (Fed. Cir. 1986):                                                                        
                     If a prima facie case is made in the first instance, and if the applicant comes                     
                     forward with reasonable rebuttal, whether buttressed by experiment, prior art                       
                     references, or argument, the entire merits of the matter are to be reweighed.                       
                     In re Piasecki, 745 F.2d 1468, 1472, 223 USPQ 785, 788 (Fed. Cir. 1984).                            
                     We find that the examiner errs in only taking into account the similarities of the                  
              reference and claimed liver conditions, and in failing to reevaluate the evidence and to                   
              account for the differences between the liver conditions described by Podda and                            
              Shironaga and the NASH condition.  In particular, the examiner has failed to rebut                         


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