Ex parte LINDOR - Page 7




              Appeal No. 1998-2267                                                                                       
              Application 08/339,084                                                                                     



              statements and evidence, Kaplowitz, cited by appellant which would reasonably appear to                    
              establish that NASH is distinct from the fatty liver condition described by Shironaga and                  
              the conditions described by Podda.                                                                         
                     After evidence or arguments are submitted by the appellant in response to rejection                 
              based on obviousness, patentability is determined on the totality of the record, by a                      
              preponderance of evidence with due consideration to persuasiveness of the argument.  On                    
              balance, we believe that the totality of the evidence presented by the examiner and                        
              appellant weighs in favor of finding the claimed invention to be non-obvious in view of the                
              cited references.  We find the examiner has not established on the record before us that                   
              the cited references both suggest the claimed subject matter and reveal a reasonable                       
              expectation of success to one reasonably skilled in the art.   The rejection of the claims for             
              obviousness of the claimed invention is reversed.                                                          















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