Ex Parte COASSIN et al - Page 3




          Appeal No. 1998-3050                                                        
          Application No. 08/586,116                                                  


          rejected claims stand or fall together."  Accordingly, all the              
          appealed claims stand or fall together with claim 77.                       
               We have thoroughly reviewed each of appellants' arguments              
          for patentability.  However, we are in full agreement with the              
          examiner that the claimed subject matter would have been prima              
          facie obvious to one of ordinary skill in the art within the                
          meaning of § 103 in view of the applied prior art.  Accordingly,            
          we will sustain the examiner's rejection.                                   
               As correctly pointed out by the examiner, Wainright, like              
          appellants, discloses a pipette tip bearing a substrate                     
          comprising a reactant binding agent for a target biomolecule,               
          wherein the target biomolecule is aspirated into the pipette tip            
          for contacting the reactant binding agents.  Indeed, appellants             
          acknowledge at page 8 of the Brief that Wainright discloses the             
          presently claimed binding agent being for a target molecule, the            
          substrate bearing the binding agent being disposed within a                 
          pipette tip, the pipette tip being in combination with means for            
          aspirating the sample, such means being capable of aspirating the           
          sample through the first end of the pipette by acting upon the              
          second end of the pipette.  As recognized by the examiner,                  
          Wainright does not specifically teach a plurality of binding                
          agents being in a spaced-apart relation on a substrate strip that           


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