Ex parte JANOFF et al. - Page 10




              Appeal No. 1999-0161                                                                                            
              Application 08/441,567                                                                                          


              diameter, time and temperature as required by claims 14 and 50.3  In view of the above,                         

              the examiner has not established a prima facie case obviousness and the rejection under                         
              35 U.S.C. 103 over Janoff in view of Madden is reversed.                                                        


              35 U.S.C. ' 103                                                                                                 

                      Claims 61-70 are rejected under 35 U.S.C. ' 103 as unpatentable for obviousness                         

              over Janoff in view of Madden and Huang.                                                                        
                                                                                                                              
                      3  We find both the examiner=s and appellants' arguments with respect to the                            
              teachings of the particle size of the lipid particles of Madden to be confusing, especially in                  
              view of the fact that an inaccurate conversion of Angstroms to nanometers (nm) has been                         
              made and relied upon in the record.  We note that the 1000 D diameter phospholipid of                           
              Madden (page 150, column 2) converts to 100 nm and not 10,000 nm as argued by                                   
              appellants and as accepted by the examiner.  Brief, page 4;  Answer, page 9.                                    


















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