Ex parte JANOFF et al. - Page 11




              Appeal No. 1999-0161                                                                                            
              Application 08/441,567                                                                                          


                      The combination of Janoff and Madden is discussed above.  Huang is relied on by                         
              the examiner for the disclosure of solid core colloidal gold particles coated with                              
              phospholipid derivatives.   The solid core liposomes of Huang comprise bilamellar lipid                         
              particles.   See abstract.   In contrast, the coated beads as depicted in Figure 2 of the                       
              present invention comprise a bonding layer over which is applied a phospholipid                                 
              monolayer.   Specification, page 12, paragraph 1.   It would appear that the coated gold                        
              particles of Huang and the claimed particles are of a different lipid structure.                                
                      We find that Huang fails to overcome the above noted deficiencies of the                                
              combination of Janoff and Madden.   Therefore, the rejection of claims 61-70  over Janoff                       
              in view of Madden and Huang is reversed.                                                                        


              35 U.S.C. ' 112, second paragraph                                                                               

                      Claims 14-20 and 50-70 are rejected under 35 U.S.C. ' 112, second paragraph, for                        

              failing to particularly point out and distinctly claim the subject matter which appellant                       
              regards as the invention. The examiner's focus during examination of claims for                                 
              compliance with the requirement for definiteness of 35 U.S.C. ' 112, second paragraph, is                       

              whether the claims meet the threshold requirements of clarity and precision, not whether                        
              more suitable language or modes of expression are available.  As stated above, if the                           
              scope of a claim would be reasonably ascertainable by those skilled in the art, then the                        


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