Ex parte TROFAST et al. - Page 13




          Appeal No. 1999-0400                                                        
          Application No. 08/316,938                                                  

         IV. The 35 U.S.C. § 103(a) rejection of claim 4 as being                     
         unpatentable over Edwards in view of Szczesny, Edmonds, Bremer,              
         Gibson, Moriya and Watson                                                    
              We shall sustain the standing 35 U.S.C. § 103(a) rejection              
         of claim 4 as being unpatentable over Edwards in view of                     
         Szczesny, Edmonds, Bremer, Gibson, Moriya and Watson since this              
         claim stands or falls with claim 1.                                          
         V. The 35 U.S.C. § 103(a) rejection of claims 1, 7, 8, 12, 14/1              
         and 31/1 as being unpatentable over Sipos in view of Szczesny,               
         Edmonds and Bremer                                                           
              Sipos discloses a process for preparing a buffered bile                 
         acid (UDCA) composition for ingestion by mammals to treat a                  
         variety of medical ailments.  The process includes the steps of              
         (1) micropulverizing the UDCA in the presence of a suitable                  
         buffer salt to obtain an ultrafine particle blend of buffered-               
         UDCA, (2) wetting the blend with a suitable liquid to cause it               
         to stick together, (3) granulating or extruding the blend                    
         through a 10 to 18 mesh S/S screen using an                                  
         oscillating/reciprocating granulator or a twin-screw extruder                
         at a medium-to-high speed, (4) classifying the granulated                    
         particles in a uni-sizer vessel that rotates at 15 to 45 rpm                 

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