Ex parte GRANDE et al. - Page 8




          Appeal No. 1999-0427                                                        
          Application 08/782,272                                                      


          that it set forth exemplary ranges for the dimensions of the                
          microchannels, but the specification does not indicate that                 
          the dimensions should be otherwise limited in any manner to                 
          practice the invention.  Therefore, we do not sustain the                   
          examiner’s rejection of claims 1-37 as being based upon an                  
          inadequate written description under the first paragraph of 35              
          U.S.C. § 112.                                                               
          We now consider the rejections under 35 U.S.C. § 103.                       
          In rejecting claims under 35 U.S.C. § 103, it is incumbent                  
          upon the examiner to establish a factual basis to support the               
          legal conclusion of obviousness.  See In re Fine, 837 F.2d                  
          1071, 1073, 5 USPQ2d 1596, 1598 (Fed. Cir. 1988).  In so                    
          doing, the examiner is expected to make the factual                         
          determinations set forth in Graham v. John Deere Co., 383 U.S.              
          1, 17, 148 USPQ 459, 467 (1966), and to provide a reason why                
          one having ordinary skill in the pertinent art would have been              
          led to modify the prior art or to combine prior art references              
          to arrive at the claimed invention.  Such reason must stem                  
          from some teaching, suggestion or implication in the prior art              
          as a whole or knowledge generally available to one having                   
          ordinary skill in the art.  Uniroyal, Inc. v. Rudkin-Wiley                  
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