Ex Parte RANGANATHAN et al - Page 8




              Appeal No. 1999-1155                                                                                        
              Application No. 08/241,253                                                                                  
              Enablement                                                                                                  
                     In view of its brevity, we reproduce the examiner’s rejection in its entirety:                       
                     The terms ‘optionally substituted’, functional groups capable of forming a                           
                     conjugate with a biomolecule are of such staggering breadth, the                                     
                     specification fails in meeting with the enablement (how to make)                                     
                     requirement i.e. how these plethora of diverse molecules are conjugated                              
                     with the instant macromolecules.  The long list of biomolecules on page                              
                     18, peptides, polypeptides, oligosaccharides . . . fragments of RNA, DNA                             
                     are too diverse chemically and too functional legally.                                               
                     It is well settled that the examiner bears the initial burden of providing reasons                   
              why a supporting disclosure does not enable a claim.  In re Marzocchi, 439 F.2d 220,                        
              223, 169 USPQ 367, 369 (CCPA 1971).  While the claims are indeed broad, we agree                            
              with appellants that the examiner has not provided a reasonable basis to question                           
              whether the specification would enable one skilled in the art to make the claimed                           
              compounds, particularly in light of Dr. Ranganathan’s assertion that “[t]he conjugation of                  
              the groups . . . in [the] claims . . . with a biomolecule of the claims is a process well                   
              known in the art” and “a matter of routine.”5  Accordingly, the rejection is reversed.                      
              Indefiniteness                                                                                              
                     Again, in view of its brevity, we reproduce the examiner’s rejection:                                



                     4(...continued)                                                                                      
              obviousness, we find it unnecessary to comment on the declaration submitted April 21,                       
              1997 under 37 CFR § 1.132 as it pertains to unexpected properties of the claimed                            
              compounds.  In re Geiger, 815 F.2d 686, 688, 2 USPQ2d 1276, 1278 (Fed. Cir. 1987).                          
                     5 See paragraph 13 of the declaration submitted under the provisions of 37 CFR                       
              § 1.132 (paper no. 17, April 21, 1997).                                                                     
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