Appeal No. 1999-1313
Application 08/448,097
38. A recombinant cloning or expression vector containing nucleic acid encoding
essentially pure protein “e” of Haemophilus influenzae or a peptide of protein “e”
comprising an epitope or epitopes thereof.
88. A method of producing essentially pure protein “e” of Haemophilus influenzae
which comprises transforming, transducing or transfecting an infectious microorganism
with the vector of Claim 38 and culturing the infectious microorganism under conditions
which permit the expression of said protein “e” by the infectious microorgaism.
The examiner relies on the following references:
Granoff et al (Granoff) ”Prospects for the Prevention of Hemophilus influenzae Type b
Disease by Immunization, The Journal of Infectious Diseases, vol 153, no.3 pp 448-461,
March 1986
Deich et al (Deich), “Cloning of genes encoding 15,000-Dalton Pepitsoglycan-Associated
Outer membrane Lipoprotein and an Antigenically Related 15,000-Dalton Protein from
Haemophilus influenzae,” Journal of Bacteriology vol.170 no2, pp 489-498, February 1988
Maniatis et al (Maniatis) Molecular Cloning: A Laboratory Manual, Editor: Sambrook,
Fritsch, Maniatis, vol. 2-3 1989.
In the Examiner’s Answer, page 2, § 10, the examiner withdrew a previously
entered rejection of claims under 35 U.S.C. 112, 1st paragraph. The sole issue remaining
on appeal is whether the examiner erred in rejecting claims 28-30, 38-46, 81-83, and 88
under 35 U.S.C. 103 as unpatentable over the combined disclosures of Granoff, Deich,
and Maniatis.
We reverse.
BACKGROUND
Nontypable Haemophilus influenzae cause diseases in adults, children, and young
adults (specification, page 1). Antiserum directed against the capsular polysaccharide of
2
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