Appeal No. 1999-1313 Application 08/448,097 provide protection against bacteremia, and that epitopes of P4 were not detectable at the cell surface. Therefore the reference provides inadequate reason, suggestion, or motivation to choose this particular protein for further work, and we agree with appellants that one of ordinary skill would have been dissuaded from attempting to obtain the gene encoding protein “e”. The examiner further argues, in rebuttal to the arguments advanced in the brief, that “the nucleic acids encoding claimed proteins or fragments can be used as probes in hybridization assays,” (Examiner’s Answer, page 5). However, the examiner does not point to any reason, suggestion, or motivation, stemming from the prior art,which would have led a person having ordinary skill to select the P4/”e” protein coding sequence for this purpose. We conclude that the examiner has not met the initial burden of establishing unpatentability. The examiner’s decision, rejecting claims 28-30, 38-46, 81-83, and 88 under 35 U.S.C. § 103, is reversed. No time period for taking any subsequent action in connection with this appeal may be extended under 37 CFR § 1.136(a). REVERSED ) Sherman D. Winters ) Administrative Patent Judge ) ) ) ) BOARD OF PATENT William F. Smith ) 6Page: Previous 1 2 3 4 5 6 7 8 NextLast modified: November 3, 2007