Ex parte GREEN et al. - Page 6




                  Appeal No.  1999-1313                                                                                                                   
                  Application 08/448,097                                                                                                                  

                  provide protection against bacteremia, and that epitopes of P4 were not detectable at the                                               
                  cell surface. Therefore the reference provides inadequate reason, suggestion, or                                                        
                  motivation to choose this particular protein for further work, and we agree with appellants                                             
                  that one of ordinary skill would have been dissuaded from attempting to obtain the gene                                                 
                  encoding protein “e”. The examiner further argues, in rebuttal to the arguments advanced in                                             
                  the brief, that “the nucleic acids encoding claimed proteins or fragments can be used as                                                
                  probes in hybridization assays,” (Examiner’s Answer, page 5).  However, the examiner                                                    
                  does not point to any reason, suggestion, or motivation, stemming from the prior art,which                                              
                  would have led a person having ordinary skill to select the P4/”e” protein coding sequence                                              
                  for this purpose.                                                                                                                       
                           We conclude that the examiner has not met the initial burden of establishing                                                   
                  unpatentability.  The examiner’s decision, rejecting claims 28-30, 38-46, 81-83, and 88                                                 
                  under 35 U.S.C. § 103, is reversed.                                                                                                     
                           No time period for taking any subsequent action in connection with this appeal may                                             
                  be extended under 37 CFR § 1.136(a).                                                                                                    
                                                                    REVERSED                                                                              
                                                                                                   )                                                      
                                                      Sherman D. Winters                           )                                                      
                                                      Administrative Patent Judge                  )                                                      
                                                                                                   )                                                      
                                                                                                   )                                                      
                                                                                                   ) BOARD OF PATENT                                      
                                                      William F.  Smith                            )                                                      

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