Ex parte VALLE et al - Page 2




             Appeal No.  1999-1417                                                                                    
             Application 08/268,730                                                                                   



                                               Representative Claims                                                  
                    Claims 74 and 76, which are illustrative of the subject matter on appeal, read as                 
             follows:                                                                                                 
                    74.  A pharmaceutical composition containing, as active ingredient, an N-acyl-                    
             lysoganglioside wherein the acyl group is derived from an aliphatic acid having from 2 to                
             12 carbon atoms, substituted with at least one polar group selected from the group                       
             consisting of                                                                                            
                    chlorine and fluorine and etherified hydroxy groups                                               
                    or esters or amides of the sialic carboxy groups of said N-acyl-lysogangliosides,                 
             inner esters of said N-acyl-lysogangliosides, peracylated derivatives of said N-acyl-                    
             lysogangliosides, metal salts or organic base salts of said N-acyl-lysogangliosides having               
             acid groups, acid addition salts of said N-acyl-lysogangliosides and mixtures of said N-                 
             acyl-lysogangliosides, together with a pharmaceutically acceptable excipient.                            


                    76.  A method of treating  disorders related to excitatory amino acid-induced                     
             neurotoxicity wherein an N-acyl-lysoganglioside wherein the acyl group is derived from an                
             aliphatic acid having from 2 to 12 carbon atoms, substituted with at least one polar group               
             selected from the group consisting of                                                                    
                    chlorine and fluorine and etherified hydroxy groups                                               

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