Ex parte VALLE et al - Page 12




                   Appeal No.  1999-1417                                                                                                                            
                   Application 08/268,730                                                                                                                           

                   Second, as best we can ascertain from the briefings, applicants do not point to any                                                              
                   specific passage or passages in the literature citations listed in the specification,                                                            
                   paragraph bridging pages 13 and 14.  Nor does it appear that applicants have even                                                                
                   supplied copies of these references for the record.  Viewing the situation in this light, we                                                     
                   find that applicants’ argument predicated on pages 13 and 14 of the specification is                                                             
                   incomplete.  Third, according to applicants, an advantage of the products of the present                                                         
                   invention (N-acyl-lysogangliosides), which “sets them apart” from gangliosides, is their                                                         
                   ability to prevent and to combat neurotoxic action (specification, paragraph bridging pages                                                      
                   15 and 16).                                                                                                                                      
                            In their Appeal Brief and Reply Brief, applicants refer to several literature articles                                                  
                                                                                                    1                                                               
                   published after the effective filing date of this application.   It is not entirely clear, however,                                              
                   why applicants rely on these post-dated articles.  To the extent that applicants rely on these                                                   
                   articles to “supplement” their specification, or to “substantiate” procedures outlined in the                                                    
                   specification (Appeal Brief, sentence bridging pages 18                                                                                          
                   and 19; and page 22, last paragraph), such reliance is misplaced.  See In re Glass,                                                              
                   492 F.2d 1228, 1232, 181 USPQ 31, 34 (CCPA 1974); Ex parte Hitzeman, 9 USPQ2d                                                                    
                   1821, 1823-24 (Bd. Pat. App. & Interf. 1987).  To the extent that applicants rely on these                                                       


                            1This application is a continuation of parent application 07/443,657, filed                                                             
                   November 30, 1989.  Further, according to the examiner, applicants “have an Italian                                                              
                   foreign priority date of 12-02-88,” based on Italian application 48618A/88 (Examiner’s                                                           
                   Answer, page 6, first paragraph).                                                                                                                
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