Appeal No. 1999-1458
Application No. 07/943,812
Claim 1 is illustrative of the subject matter on appeal and is reproduced
below:
1. An isolated and purified DNA molecule comprising a radiation
responsive enhancer-promoter operatively linked to an encoding
region that encodes at least one polypeptide, other than CAT, that one
desires to have expressed in a radiation responsive manner, which
encoding region is operatively linked to a transcription-terminating
region, wherein said radiation responsive enhancer-promoter
comprises a portion of the CArG domain from –550 to –50 of an Egr-1
promoter or a c-jun promoter.
The references relied upon by the examiner are:
Hung et al. (Hung) 4,370,417 Jan. 25, 1983
Mark et al. (Mark) 4,677,064 Jun. 30, 1987
Brent et al. (Brent) 4,833,080 May 23, 1989
Orr et al. (Orr) 4,835,098 May 30, 1989
Johnsson et al. (Johnsson), “The c-sis Gene Encodes a Precursor of the B
Chain of Platelet-Derived Growth Factor,” The EMBO Journal, Vol. 3, No. 5,
pp. 921-928 (1984)
Angel et al. (Angel), “The Jun Proto-Oncogene is Positively Autoregulated by Its
Product, Jun/AP-1,” Cell, Vol. 55, pp.875-885 (1988)
Bonthron et al. (Bonthron), “Platelet-Derived Growth Factor A Chain: Gene
Structure, Chromosomal Location, and Basis for Alternative mRNA Splicing,”
Proc. Natl. Acad, Vol. 85, pp. 1492-1496 (1988)
Christy et al. (Christy), “A Gene Activated in Mouse 3T3 Cells by Serum Growth
Factors Encodes a Protein With ‘Zinc Finger’ sequences,” Proc. Natl. Acad,
Vol. 85, pp. 7857-7861 (1988)
Ghosh et al. (Ghosh), “Cloning of the p50 DNA Binding Subunit of NF- ĸB:
Homology to rel and dorsal,” Cell, Vol. 62, pp. 1019-1029 (1990)
Moolten et al. (Moolten), “Curability of Tumors Bearing Herpes Thymidine Kinase
Genes Transferred by Retroviral Vectors,” Journal of the National Cancer
Institute, Vol. 82, No. 4, pp. 297-300 (1990)
2
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