Ex Parte WEICHSELBAUM et al - Page 8


                 Appeal No. 1999-1458                                                                                     
                 Application No. 07/943,812                                                                               
                         Appellant merely shows that his novel compounds are appetite                                     
                         suppressants whereas the reference compounds are not so known.                                   
                         …  Presented with such an absence of comparative or other                                        
                         evidence with respect to the properties of the compounds and the                                 
                         claimed composition, we hold that [the] composition … would have                                 
                         been obvious from and unpatentable over the prior art.                                           
                         These cases appear to be consistent with the examiner’s conclusion                               
                 (Answer, page 11) that “[a]ppellants discovered that the promoters are …                                 
                 induced by radiation.  On the basis of this discovery, they wish to exclude others                       
                 from using the promoters in combination with any coding sequence other than                              
                 CAT, for any purpose.  The [e]xaminer’s interpretation of the law is that this is                        
                 not permitted.”  But, if one looks under the surface, the facts of record in this                        
                 case do not lead to the examiner’s conclusion.                                                           
                         The claimed invention is drawn to “[a]n isolated and purified DNA                                
                 molecule comprising a radiation responsive enhancer-promoter operatively                                 
                 linked to an encoding region that encodes at least one peptide, other than                               
                 CAT.…” According to the examiner (Answer, page 9), that the claimed promoter                             
                 is radiation responsive is an inherent property of the promoter; it is not the                           
                 “unexpected” result of combining this regulatory sequence (promoter) with a                              
                 structural sequence other than CAT.  We agree with this part of the examiner’s                           
                 analysis.  However, the analysis does not end there.                                                     
                         In responding to appellants’ arguments it appears that the examiner more                         
                 fully develops his prima facie case of obviousness.  According to the examiner                           
                 (Answer, pages 8-9) “[t]hose of ordinary skill in the art knew that any coding                           
                 sequence could be linked to any promoter for expression of the coding                                    
                 sequence.  It is obvious to substitute known equivalents for the same purpose,                           

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