Ex Parte TAKEO et al - Page 12




          Appeal No. 1999-2069                                                        
          Application 08/397,639                                                      

               We generally agree with the Examiner's response (EA10-11),             
          except for our comments in footnote 2.  In addition, we note that           
          an "interval change is defined here as a pathological change                
          which has occurred after the previous examination and before the            
          current examination" (Kano, col. 1, lines 48-51).  The "interval            
          change" has nothing inherently to do with the kind of shifts.               
          Kano discloses causes of misregistration in Fig. 12, which                  
          involve translation (e.g., due to lung expansion), rotation                 
          (e.g., due to lateral inclination), and scaling (e.g., due to A-P           
          inclination), as well as more complicated factors.  Kano relates            
          to image registration of radiation images and is very similar to            
          the disclosed and claimed subject matter except that it relates             
          to more complex misregistration problems.  Appellants do not                
          argue what language in claim 1 distinguishes over Kano.                     
               Appellants argue that Smilansky does not suggest applying              
          its inspecting method to radiation images (Br5).  The Examiner              
          responds that Kano, not Smilansky, is relied on for teaching                
          subtraction of radiation images (EA11).                                     
               We agree with the Examiner.  Smilansky evidences that one of           
          ordinary skill in the image registration art had knowledge of               
          affine transformations for image registration, in general.  One             
          of ordinary skill in the art would have been motivated to apply             
          the affine transformations taught in Smilansky because they are             


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