Ex parte LIPPS - Page 3




              Appeal No. 1999-2141                                                                                       
              Application No. 08/657,164                                                                                 



              Bougis et al. (Bougis), “Characterization of Elapidae Snake Venom Components Using                         
              Optimized Reverse-Phase High-Performance Liquid Chromatographic Conditions and                             
              Screening Assays for "-Neurotoxin and Phospholipase A  Activities,” Biochem., Vol. 25,                     
                                                                          2                                              
              pp. 7235-7243 (1986)                                                                                       
              Tyler et al. (Tyler), “Studies on the subunit structure of textilotoxin, a potent neurotoxin from          
              the venom of the Australian common brown snake (Pseudonaja textilis),” Biochim. Et                         
              Biophys. Acta, Vol. 915, pp. 210-216 (1987)                                                                
              Hearn, “General strategies in the separation of proteins by high-performance liquid                        
              chromatographic methods,” Journal of Chromatography, Vol. 418, pp. 3-26 (1987)                             
              Robert K. Scopes (Scopes), Protein Purification Principles and Practice 3rd Ed., 154-158                   
              (Charles Cantor, ed., Springer-Verlag)  (1993)                                                             

              Grounds of Rejection                                                                                       
              1.   Claims 8-11 stand rejected under 35 U.S.C. § 103 as unpatentable as obvious over                      
              Lind and Fohlman taken with Scopes, Tyler and Bougis.                                                      
              2.  Claims 8-11 stand rejected under 35 U.S.C. § 103 as unpatentable as obvious over                       
              Haast ‘762 and ’902 in view of Tyler and Bougis.                                                           
              3.  Claims 8-10 stand rejected under 35 U.S.C. § 112, first paragraph, as the specification,               
              as originally filed, does not provide support for the invention as now claimed.                            
                                                      DECISION                                                           
                     In reaching our decision in this appeal, we have given careful consideration to the                 
              appellant’s specification and claims, to the applied prior art references, and to the                      
              respective positions articulated by the appellant and the examiner.                                        

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