Appeal No. 2000-1909 Page 8
Application No. 08/790,528
the active ingredient. See Caldwell, page 2, first full paragraph. Gottwald
teaches that H-2 antagonists, such as cimetidine, have a very bitter taste, and
thus they are usually administered as a tablet. Moreover, Gottwald also teaches
that a tablet containing the antagonist should release the active ingredient rapidly
and completely upon reaching the stomach. See Gottwald, page 3, lines 5-23.
In addition, France teaches that H-2 receptor antagonists are bitter, and thus
have palatability problems. See France, page 2. These disclosures thus teach
away from placing an H-2 receptor antagonist integral with a chewing gum matrix
because of the problems of bioavailability of the antagonist, as well as its bitter
taste, which, as noted by France, would reduce patient compliance.
Page: Previous 1 2 3 4 5 6 7 8 9 10 Next
Last modified: November 3, 2007