Ex Parte TACKETT - Page 4


                 Appeal No. 2001-1925                                                           Page 4                    
                 Application No. 08/677,838                                                                               

                         The one relevant portion of the rejection discusses the examples in the                          
                 specification, and the results as presented by the Figures of the application of                         
                 the nuclease solution to the skin for the reduction of wrinkles.  That portion of the                    
                 rejection is reproduced below.                                                                           
                         Though the specification provides examples were [sic] the                                        
                         nuclease solution is applied to the skin, the results of these                                   
                         examples (i.e., the photographs) are equivocal.  For instance, in                                
                         Figures 1, 2, and 3, it is not possible to accurately assess the                                 
                         amount of wrinkling present due to the differences in lighting and                               
                         facial expression.  In this example, the specification states that                               
                         Figure 1 is a photograph of a sixty-four year old female before                                  
                         treatment with the invention, and that Figure 2 is a photograph of                               
                         the same woman after treatment.  However, upon observation, the                                  
                         notable differences in the lighting preclude an accurate assessment                              
                         of the amount of wrinkling and discoloration.  Furthermore, while                                
                         the photograph in Figure 3 is a clear, close-up profile shot of the                              
                         same woman after treatment, her facial expression is different (i.e.,                            
                         not smiling which alone reduces folds around the eyes), and                                      
                         moreover, the disclosure fails to provide a corresponding before                                 
                         treatment photograph with which to accurately compare the results.                               
                         Likewise, Figures 4, 5, and 6 are ambiguous as well.  Figures 4 and                              
                         4 are the before treatment photographs of a forty-three year old                                 
                         female, yet once again, the lighting combined with the distance are                              
                         such that no fine details of the skin can be ascertained in Figure 4.                            
                         Accordingly, that leaves Figure 5 as the only before treatment                                   
                         close-up photograph with which to compare to the after treatment                                 
                         photographs of Figures 6 and 7.  Yet, in this photograph (Figure 5)                              
                         the woman appears to be squinting, something which she is not                                    
                         doing in the other photographs (Figures 6 & 7).  Consequently, the                               
                         absence of the folds present around the eye in Figures 6 and 7                                   
                         could be the result of her facial expression or the absence thereof                              
                         (i.e., no squinting).  In addition, the pictures do not even address                             
                         the ability of the claimed method to reduce skin discoloration.                                  
                         Accordingly, the pictures are equivocal and do not support the                                   
                         notion that the claimed method will in fact reduce wrinkles and                                  
                         discoloration in the skin.                                                                       
                 Answer, pages 3-4.                                                                                       








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