Appeal No. 2001-0163
Application No. 08/951,502
THE INVENTION
The Appellant’s claimed invention relates to a method of separating optical
isomers in a simulated moving bed chromatography system which utilizes a packing
material for the optical resolution of an optical isomer mixture. The packing material
used is composed of particles of a polysaccharide derivative unsupported by silica gel.
According to the Appellant, the unsupported polysaccharide derivative provides an
excellent ability to resolve and separate optical isomers in a high pressure
environment. (Brief, p. 2). Claim 11 which is representative of the invention is
reproduced below:
11. A method of separation of optical isomers using a simulated moving
bed chromatographic apparatus which comprises:
forming a circulation circuit comprising a plurality of columns each
provided with an inlet port and an outlet port and packed with particles
of polysaccharide derivatives, said columns being serially and endlessly
connected so as to achieve serial and unidirectional fluid flow through
said columns, wherein the particles of polysaccharide derivatives are not
supported on a silica gel carrier;
introducing an optical isomer mixture to be separated into one of the
columns via the inlet port thereof in order to cause adsorbable or
strongly adsorbable substances to become adsorbed on the particles of
polysaccharide derivatives in the column and several columns that
follow;
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