Ex Parte IKEDA - Page 3




             Appeal No. 2001-0163                                                                                    
             Application No. 08/951,502                                                                              

                     drawing out a solution rich in the other substances being non-adsorbable                        
                     or poorly adsorbable on the particles of polysaccharide derivatives via                         
                     the outlet port of another one of the columns;                                                  
                     introducing an eluent into still another one of the columns via the inlet                       
                     port thereof;                                                                                   
                     drawing out a solution rich in the adsorbable or strongly adsorbable                            
                     substances via the outlet port of further another one of the columns; and                       
                     passing the remaining solution and the eluent through the circuit and                           
                     recirculating them,                                                                             
                     wherein the position for introducing the eluent, the position for drawing                       
                     out the solution containing the adsorbable or strongly adsorbable                               
                     substances, the position for introducing the optical isomer mixture and                         
                     the position for drawing out the solution containing the non-adsorbable                         
                     or weakly adsorbable substances are arranged in the circulation in this                         
                     order along the direction of the fluid flow, and the positions are                              
                     successively moved in the direction of the fluid flow in the circuit                            
                     intermittently.                                                                                 














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